Maden Lab
research ongoing on individual differences/phenotypic variation in tissue regeneration in African spiny mice
Publications:
journals.biologists.com/dev/article/147/4/dev167718/223165/Model-systems-for-regeneration-the-spiny-mouse
https://www.nature.com/articles/s41536-020-00111-1
Publications:
journals.biologists.com/dev/article/147/4/dev167718/223165/Model-systems-for-regeneration-the-spiny-mouse
https://www.nature.com/articles/s41536-020-00111-1
Würbel Lab
Are mice of the same dominance rank more similar to one another across cages than within the cage, despite their shared housing environment?
We found that male and female lab mice in same-sex cages frequently form dynamic and unstable dominance relationships. This contradicts the recent literature, but echoes early research on home-cage dominance behavior and is likely due to experiments neglecting the stability of ranks across multiple weeks.
We found that social context, defined as dominance status and hierarchical organization, more frequently accounted for variability in phenotypic traits than the cage context, defined as shared housing environment.
We analyzed all current experiments measuring phenotypic traits in relation to social dominance rank in lab mice and found that most studies report no difference between dominance ranks. There is also great heterogeneity in the current literature especially concerning the methodology of measuring dominance.
selected publications:
www.nature.com/articles/s41598-018-24624-4
www.nature.com/articles/s41598-019-49612-0
www.frontiersin.org/articles/10.3389/fnbeh.2020.624036/full
We found that male and female lab mice in same-sex cages frequently form dynamic and unstable dominance relationships. This contradicts the recent literature, but echoes early research on home-cage dominance behavior and is likely due to experiments neglecting the stability of ranks across multiple weeks.
We found that social context, defined as dominance status and hierarchical organization, more frequently accounted for variability in phenotypic traits than the cage context, defined as shared housing environment.
We analyzed all current experiments measuring phenotypic traits in relation to social dominance rank in lab mice and found that most studies report no difference between dominance ranks. There is also great heterogeneity in the current literature especially concerning the methodology of measuring dominance.
selected publications:
www.nature.com/articles/s41598-018-24624-4
www.nature.com/articles/s41598-019-49612-0
www.frontiersin.org/articles/10.3389/fnbeh.2020.624036/full
Does variability in mouse housing contribute to irreproducibility and phenotypic variation?
We found that varying space allowance and group size has little effect beyond increasing risk for escalating aggression in male mice
We found that varying environmental enrichment does not increase variation in experimental results, and super-enrichment may improve animal welfare
We found that variable weaning age and housing condition (group vs. single) has little effect on phenotypic variation
selected publications:
www.nature.com/articles/s41598-017-18493-6
www.frontiersin.org/articles/10.3389/fnbeh.2018.00232/full
https://www.nature.com/articles/s41598-020-68549-3
We found that varying space allowance and group size has little effect beyond increasing risk for escalating aggression in male mice
We found that varying environmental enrichment does not increase variation in experimental results, and super-enrichment may improve animal welfare
We found that variable weaning age and housing condition (group vs. single) has little effect on phenotypic variation
selected publications:
www.nature.com/articles/s41598-017-18493-6
www.frontiersin.org/articles/10.3389/fnbeh.2018.00232/full
https://www.nature.com/articles/s41598-020-68549-3
Ronca Lab
Can we find early biomarkers of neurological dysfunction related to obstetric complications?
We found that rat offspring exposed to perinatal asphyxia have abnormal social behavior and reduced choline and glutamate metabolites in the dopaminergic pathways of the brain
Masters thesis: libres.uncg.edu/ir/uncg/listing.aspx?id=16237
We found that rat offspring exposed to perinatal asphyxia have abnormal social behavior and reduced choline and glutamate metabolites in the dopaminergic pathways of the brain
Masters thesis: libres.uncg.edu/ir/uncg/listing.aspx?id=16237